Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth

摘要：

Dear Editor,The tumor-microenvironment interactions play important roles in tumor progression, metastasis, and therapeutic resistance,1 and increasing evidence indicates that tumor cell-derived exosomes can systematically modulate or reprogram the tumor microenvironment by transferring molecules, such as microRNAs, mRNAs, and proteins from donor cells to recipient cells.2 PD-L1 is a classical immune surface protein, which inhibits anti-tumor function of T cells by binding to its receptor programmed cell death-1 (PD-1) and effectively protects tumor from immune surveillance.3 Exosomes have been reported to contain certain types of proteins, including membrane proteins, e.g., EGFR and MET, that promote cancer metastasis.4,5 As a membrane-bound protein, whether PD-L1 exists in cancer cell-derived exosomes and whether it plays a role in tumor progress are largely unknown.

所属期刊栏目：28

资助基金：This work was funded in part by the following: National Institutes of HealthCCSG CA016672;RO1 CA211615;Cancer Prevention & Research Institutes of TexasDP150052 and RP160710;National Breast Cancer Foundation, Inc;Breast Cancer Research FoundationBCRF-17-069;Patel Memorial Breast Cancer Endowment Fund;The University of Texas MD Anderson-China Medical University and Hospital Sister Institution Fund;Center for Biological Pathways;Ministry of Science and Technology, International Research-intensive Centers of Excellence in TaiwanI-RiCE, MOST 105-2911-1-002-302;Ministry of Health and Welfare, China Medical University Hospital Cancer Research Center of ExcellenceMOHW106-TDU-B-212-144003;The University of Texas MD Anderson Cancer Center Odyssey Fellowship Program;The National Research Foundation of Korea grant for the Global Core Research Center funded by the Korean governmentMSIP 2011-0030001 to J.-H.C

在线出版日期：2018-10-10（万方平台首次上网日期，不代表论文的发表时间）

页数：共3页

页码：862-864