Embryonic senescent cells re-enter cell cycle and contribute to tissues after birth
Dear Editor,Cellular senescence (or senescence) has been regarded as a stable form of cell cycle arrest by in vitro cell culture experiments.1 Recent studies indicate that senescence is associated with aging and diseases, including cancers.2,3 For instances, it suppresses tumor progression by halting the growth of premalignant cells,4 and promotes wound healing by preventing excessive tissue fibrosis or induction of cell dedifferentiation.5,6 Targeting senescent cells could restore tissue homeostasis in response to aging, chemotoxicity, or injury.
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We thank Shanghai Model Organisms Center, Inc. SMOC for mouse generation. This study was supported by the Strategic Priority Research Program of the Chinese Academy of SciencesCAS, XDB19000000 and XDA16020204;the National Natural Science Foundation of China31730112, 91639302, 31625019, 81761138040, and 31701292;the National Key Research & Development Program of ChinaSQ2018YFA010113, 2016YFC1300600, and 2017YFC1001303;Royal Society-Newton Advanced FellowshipNA170109;Research Council of Hong Kong04110515, 14111916, and C4024-16W
2018-10-10（万方平台首次上网日期，不代表论文的发表时间）
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