The genomic landscape of small cell carcinoma of the esophagus

摘要：

Dear Editor,Small cell carcinoma of the esophagus (SCCE) is the most common extrapulmonary small cell carcinoma, accounting for 1 ％-2.8％ of all esophageal carcinomas.1 Most patients with SCCE die within 2 years of diagnosis and experience a median survival of only 8-13 months.1 Due to lack of prospective data and its similarities in histological appearance and clinical behavior to small cell lung cancer (SCLC), treatments for SCCE are adopted from well-established therapeutic strategies for SCLC.2 Chemotherapy is initially effective for SCCE, but most patients suffer a rapid recurrence and die within a few months.2 More effective and precise treatment strategies for SCCE are urgently required, but have been hampered by lack of information on the molecular drivers of this deadly cancer.3

所属期刊栏目：28

资助基金：We are grateful to all the patients who contributed their tumor specimens. We thank Professor Xinyuan Guan;Professor Musheng Zeng University of Sun Yat-sen University Cancer Center, China for suggestions. This work was supported by the National Natural Science Foundation of China81572392;the Major Special Project from Guangzhou Health and Medical Collaborative Innovation15570006;the Natural Science Foundation of Guangdong Province2014A030312015;the Science and Technology Program of Guangdong Province2015B020232008;the Science and Technology Program of Guangzhou15570006;the Pearl River Nova Program of Guangzhou201610010068;the Guangdong Esophageal Cancer Institute Science and Technology ProgramQ201517;the Fundamental Research Funds for the Central Universities14ykpy40;the Guangzhou Health-Medical Collaborative Innovation Project201508020247;the National Key Research and Development Program of China2017YFC1308900;the China Postdoctoral Science Foundation2017M610573;the Guangzhou Health-Medical Collaborative Innovation Project 201400000004-5. F Wang is a recipient of the Outstanding Young Talents Program of Sun Yat-sen University and the Young Physician Scientist Program of Sun Yat-sen University Cancer Center

在线出版日期：2018-10-10（万方平台首次上网日期，不代表论文的发表时间）

页数：共4页

页码：771-774