Pan-cancer analysis of somatic mutations across 21 neuroendocrine tumor types
Dear Editor,Neuroendocrine tumors (NETs) comprise a heterogeneous spectrum of neoplasms originating from neuroendocrine cells in various organs — most commonly in the endocrine glands and the gastrointestinal tract.1 The molecular and etiological features of NETs arising from different organs are still far from clarified. Therefore, systematic analysis of genomic alternations and their contribution to core pathways in NETs is urgently needed for the development of novel diagnostic, therapeutic strategies and personalized management of patients. Here, we investigated somatic mutations across 21 NET types through pan-cancer analysis and identified 86 candidate driver genes. Further analysis of druggability and panel sequencing of these genes provide potential diagnostic and therapeutic targets for NETs.
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We thank Dr. Huanming Yang, Dr. Qiang Gao, Mr. Xuanlin Huang and Ms. Peina Du at BGI-Shenzhen for the helpful discussion. This work is supported by the National Natural Science Foundation of China81522032 to Y.C. and 81530020 to G.N.;the National Key Research and Development Program2016YFC0905001 and 2017YFC0909703 to Y.C.;the Shanghai Rising-Star Program15QA1402900 to Y.C.;the National Human Genome Research InstituteU01HG006517 to L.D.
2018-08-28（万方平台首次上网日期，不代表论文的发表时间）
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601-604
