Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer
Dear Editor,Esophageal cancer is a serious malignancy with high rates of incidence and mortality. It ranked the eighth most common cancer and the sixth leading cause of cancer death worldwide.1 About 87％ of esophageal cancers are esophageal squamous cell carcinomas (ESCCs), with the highest incidence found in South-Eastern and Central Asia.2 Notably, almost half of the global esophageal cancers occur in China.3 The 5-year survival rate of esophageal cancer patients is only 15 to 20％, partly due to late clinical presentation and lack of early diagnostic biomarkers.4 Therefore, exploring a highly sensitive and specific early diagnosis method is in urgent need.
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the National Key R&D Program of China 2016YFC0900300, NSFC 31670895/U1504831/31741074, Major Science and Technology Project of Henan Province161100310100;CAS Strategic Priority Research Program XDA16010108/XDB14030300, CAS Hundred Talent Program, Youth Innovation Promotion Association, CAS 2016097. Shanghai Epican Genetech sponsor part of the sequencing cost
2018-08-28（万方平台首次上网日期，不代表论文的发表时间）
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597-600
