Silencing of developmental genes by H3K27me3 and DNA methylation reflects the discrepant plasticity of embryonic and extraembryonic lineages
Dear Editor,One of the most important topics in mammalian embryogenesis is the generation of multiple cell lineages. Briefly, one single-cell totipotent zygote develops into the inner cell mass (ICM) and trophectoderm (TE) at the blastocyst stage. Afterwards, the ICM further generates the epiblast cells and finally forms multiple somatic cell lineages, while the TE develops into extraembryonic ectoderm (ExE) cells and eventually forms the placental tissue. The highly ordered programming of mammalian embryo development is spatial-temporally regulated by epigenetic mechanisms. Previous work has revealed that the ICM and TE remain largely epigenetically indistinguishable,1, 2 even though there exist significant transcriptional distinctions. Recently we revealed the spatial-specific transcriptome of key development-related genes (DRGs) in mouse E7.0 gastrula, and we also noticed that these DRG-silenced gastrula regions possess distinct developmental potencies.3 However, whether there are any distinctions of epigenetic mechanisms underlying the region-specific distribution of DRGs in post implantation embryos and how these epigenetic distinctions contribute to the regionalized developmental potential in mouse embryos remain unclear.
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We thank Dr P. Tam;Dr Dangsheng Li Shanghai Institute of Biochemistry and Cell Biology for helpful advice and discussion. This work was supported in part by the Strategic Priority Research Program of the Chinese Academy of SciencesXDA16020501 and XDA16020404;the National Key Basic Research and Development Program of China2017YFA0102700, 2014CB964804, and 2015CB964500;the National Natural Science Foundation of China31430058, 31571513, 31630043, 31501178, 91519314, 31661143042, 81561138005, 31625018, and 81521002
2018-08-28（万方平台首次上网日期，不代表论文的发表时间）
共4页
593-596
