m6A mRNA methylation sustains Treg suppressive functions
Dear Editor,N6-methyladenosine (m6A) is the most abundant mRNA chemical modification,and is modulated by m6A ”writers”,”erasers” and”readers” proteins ”1-3”.In vitro experiments suggest that m6A regulates several aspects of RNA metabolism,including RNA decay,splicing and translation ”1”.Recent genetic analyses in vivo showed that m6A functions in sex determination in Drosophila ”4,5”,in maternal-to-zygotic transition and haematopoietic stem cell specification during zebrafish embryogenesis ”6,7”,in mouse spermatogenesis ”8-10”,and in mouse brain development ”11”.We recently discovered that lineage-specific deletion of the m6A”writer”enzyme METTL3 in CD4+ T cells (Mettl3f/f;CD4-Cre) led to disruption of naive T cell homeostasis ”12”.CD4+ regulatory T ceils (Tregs) comprise a critical subset of effector T cells,which are involved in resolution of inflammation and immunosuppression in tumor microenvironments ”13”.However,the potential roles of m6A mRNA modification in Treg functions in vivo are unknown.
28
We thank W Bailis,W Li,Kroehling L,J Alderman,C Lieber,J Stein and other members of the Flavell laboratory and the Li laboratory for discussions and technical support.This work was supported by Howard Hughes Medical Institute;the startup fund from the Shanghai Jiao Tong University School of Medicine;the Program for Professor of Special Appointment Eastern Scholar at Shanghai Institutions of Higher Learning;the National Natural Science Foundation of China91753141 to H-BL,81725004 to HL,31470845 and 81430033 to BS,81788104 and 31770990 to SZ;the US NIH R01-HG004361 and R35-CA209919
2018-04-04（万方平台首次上网日期，不代表论文的发表时间）
共4页
253-256
