Endothelial-specific m6A modulates mouse hematopoietic stem and progenitor cell development via Notch signaling

摘要：

Hematopoietic stem and progenitor cells (HSPCs) have been documented to be specified from hemogenic endothelial (HE) cells in the ventral wall of the dorsal aorta (DA) through the endothelial-to-hematopoietic transition (EHT) during mouse embryogenesis ”1”.N6-methyl-adenosine (m6A) is the most prevalent mRNA modification in eukaryotes.Although the function of m6A modification in cell fate determination of embryonic stem cells has been recently reported ”2”,the physiological role and the underlying mechanism of m6A modification in definitive hematopoiesis during mouse embryogenesis have not been reported yet.

所属期刊栏目：28

资助基金：grants from the National Natural Science Foundation of China31425016 and 81530004;the Ministry of Science and Technology of China2016YFA0100500;the Strategic Priority Research Program of the Chinese Academy of Sciences,ChinaXDA01010110

在线出版日期：2018-04-04（万方平台首次上网日期，不代表论文的发表时间）

页数：共4页

页码：249-252