The 11th C2H2 zinc finger and an adjacent C-terminal arm are responsible for TZAP recognition of telomeric DNA
Dear Editor,Telomere length homeostasis,dictating cellular proliferative potential,is crucial for proper cellular function.In addition to the well-known telomere shortening during cell division and lengthening by activation of telomerase or an alternative lengthening of telomeres (ALT) mechanism,telomere length is also subject to regulated rapid deletion events referred to as telomere trimming ”1”.This trimming process involves excision of telomeric structures called T-loops,which requires homologous recombination proteins XRCC3 and NBS1 ”2,3”.Recent studies showed that the balance between telomere trimming and lengthening determines telomere length in germline and stem cells,suggesting that telomere trimming should be under stringent control ”4,5”.However,the regulation of telomere trimming remains largely unknown.
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We thank the staffs of BL 19U1 beamline at National Center for Protein Science Shanghai and Shanghai Synchrotron Radiation Facility,Shanghai,China,for assistance during data collection.This work was supported by the Ministry of Science and Technology of China2016YFA0500700;the Strategic Priority Research Program of the Chinese Academy of SciencesXDB08010101;the National Natural Science Foundation of China31330018,31500590 and 31400643;the Fundamental Research Funds for the Central UniversitiesWK2070000095
2018-03-06（万方平台首次上网日期，不代表论文的发表时间）
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