TRFH domain: at the root of telomere protein evolution?
Two articles in Cell Research focus on the structure-function relationships in the shelterin complex that binds to telomeres and is essential for their stability and functions.These studies concerning both mammalian and Schizosaccharomycespombe proteins reveal unexpected structural conservation of a motif called TRFH (Telomeric Repeat Factors Homology)domain between several subunits in these complexes,providing a rationale for further dissection of the role of telomeres in chromosome stability,aging and cancer,and encouraging us to revisit the evolution of telomere proteins.
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2018-03-06(万方平台首次上网日期,不代表论文的发表时间)
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