Portending death in germinal centers-when B cells know their time is up

摘要：

B cells undergo stringent selection in germinal centers (GCs) for expression of high-affinity antibodies,however,mechanisms of negative selection of low-affinity B cell clones remain elusive.A new study by Michel Nussenzweig”s group published in Science leverages a new reporter system that marks pre-apoptotic GC B cells to dissect microanatomic regions of GCs and their role in affinity maturation.

所属期刊栏目：28

在线出版日期：2018-03-06（万方平台首次上网日期，不代表论文的发表时间）

页数：共2页

页码：5-6