PRRT2-dependent dyskinesia: cerebellar, paroxysmal and persistent
In an elegant publication in Cell Research,Tan and colleagues showed that ablation of PRRT2 in cerebellar granule cells is sufficient to induce paroxysmal kinesigenic dyskinesia.PRRT2 turns out to downregulate the presynaptic SNARE complex in granule cell axons,which in turn controis the activity patterns of Purkinje cells,the sole output of the cerebellar cortex.
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2018-03-06(万方平台首次上网日期,不代表论文的发表时间)
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