Fine-tuning type Ⅰ IFN signaling: A new chapter in the IFN saga
Type I interferon (IFN) signaling is critical for intracellular antimicrobial programmes,affecting both innate and adaptive immune responses.The paper recently published in Cell demonstrates a new regulatory mechanism of the type Ⅰ IFN signaling pathway by histone-lysine N-methyltransferase SETD2.The Janus tyrosine kinase (JAK),Signal Transducer and Activator of Transcription (STAT) proteins,and Interferon Regulatory Factor (IRF) family of transcription factors are important mediators of many cytokine systems ”1-4”.While cytokine research has impacted a number of fields,it is remarkable that the major cytokine pathways were first elucidated in the context of the same regulatory network,the type Ⅰ interferon (IFN) system.As such,one may term the series of studies as a first wave of research on cytokine induction and action.
transcription factors、signaling pathway、immune responses、tyrosine kinase
27
R73;R31
2018-01-10（万方平台首次上网日期，不代表论文的发表时间）
共2页
1407-1408
