Hunting for the mutant without the MAP(K)

摘要：

In a paper recently published in Cell Research,Yu et al.identify two MAPK-related kinases,MAPK11 and HIPK3,as positive regulators of levels of mutant huntingtin protein,a toxic species highly involved in Huntington”s disease (HD) pathology.The identification and validation of these kinases as therapeutic targets for knockdown in multiple relevant experimental model systems reveal novel potential approaches for treatment of HD.

机标关键词：experimental model

所属期刊栏目：27

分类号：R65

在线出版日期：2018-01-10（万方平台首次上网日期，不代表论文的发表时间）

页数：共2页

页码：1403-1404