A circular twist on microRNA regulation

摘要：

Circular RNAs (circRNAs) are a novel class of RNA whose physiological function has yet to be investigated.A recent publication in Science provides the first evidence of the biological relevance of a circRNA in an in vivo model and unveils an unexpected twist on their crosstalk with miRNAs.In 1993,Cocquerelle et al.”1”,inspired by the discovery of scrambled exons,investigated the existence of two nonpolyadenylated circular RNA (circRNA) isoforms generated from the ets-1 locus in human cells.In a concurrent study,Capel et al.”2” identified a circRNA arising from the Sry locus.

机标关键词：physiological function、human cells

所属期刊栏目：27

分类号：TS2;S66

在线出版日期：2018-01-10（万方平台首次上网日期，不代表论文的发表时间）

页数：共2页

页码：1401-1402