An essential role for PNLDC1 in piRNA 3”end trimming and male fertility in mice

摘要：

Dear Editor,PIWI-interacting RNAs (piRNAs) are germ cell-specific small non-coding RNAs that are essential for silencing transposable elements.Substantial efforts in the past decade have led to an understanding of how piRNAs are made.Primary piRNA biogenesis is initiated with transcription of piRNA precursors,followed by cleavage into piRNA intermediates,and finally,maturation by 3”end trimming and 2”-O-methylation.

所属期刊栏目：27

资助基金：the National Key R&D Program of China2016YFA0500902 and 2017YFA0103803;the National Basic Research Program of China2015CB943003;National Natural Science Foundation of China Grant81471502,31771651,31471228;Excellent Youth Foundation of Jiangsu Scientific Committeegrant BK20150047;Innovative and Entrepreneurial Program of Jiangsu Province.We thank Jingdi Hu Shanghai Biotechnology Corporation,Shanghai,China for small RNA analysis

在线出版日期：2017-12-08（万方平台首次上网日期，不代表论文的发表时间）

页数：共5页

页码：1392-1396