Cryo-EM structure of human DNA-PK holoenzyme

机标关键词：protein kinase、conformational changes、complex structure、core domain、DNA repair

所属期刊栏目：27

分类号：O6 ;R96

资助基金：We thank staff members of National Center for Protein Science Shanghai;Institute of Biophysics;Chinese Academy of Sciences;Biomedical Core Facility of Fudan University for their help on cryo-EM sample screening and data collection.We thank Minghong He from Prof Jinqiu Zhou”s Lab at Shanghai Institute of Biochemistry and Cell Biology for his help on kinase activity assays.We thank Prof David Chen for kindly providing the2016YFA0500700;the Strategic Priority Research Program of the Chinese Academy of SciencesXDB08000000;the National Natural Science Foundation of ChinaU1432242,31425008 and 91419301;the Program of Shanghai Subject Chief Scientist14XD1400500

在线出版日期：2017-12-08（万方平台首次上网日期，不代表论文的发表时间）

页数：共10页

页码：1341-1350