Structural step forward for NHEJ

摘要：

In a recent paper published in Cell Research,a cryo-EM structure reveals the interface between DNA-PKcs and the Ku70/80:DNA complex,together forming the DNA-dependent protein kinase holoenzyme in nonhomologous DNA end joining.Insight from this structure suggests how an allosteric rearrangement of DNA-PKcs driven by Ku70/80:DNA binding regulates kinase activity in this largest member of a family of structurally homologous phosphoinositide 3-kinase-related protein kinases that includes mTOR,ATR,and ATM.

机标关键词：protein kinases

所属期刊栏目：27

分类号：R96;R9

在线出版日期：2017-12-08（万方平台首次上网日期，不代表论文的发表时间）

页数：共3页

页码：1304-1306