Altered neurogenesis and disrupted expression of synaptic proteins in prefrontal cortex of SHANK3-deficient non-human primate

摘要：

Dear Editor,Despite substantial progress made toward understanding the molecular changes contributing to autism spectrum disorders (ASD),the neuropathophysiology underlying ASD remains poorly understood ”1,2”.Structural brain imaging in humans is valuable,but lacks resolution at the cellular level.Studies of neuropathology in humans have been hampered by the lack of high quality postmortem brains from individuals with ASD ”2”.For more than decades,mutant mice have served as major tools to dissect the pathophysiology of ASD because of the wealth of molecular and neurobiological techniques developed for studies with rodents.

机标关键词：high quality

所属期刊栏目：27

分类号：S64

资助基金：We thank Drs Weixiang Guo,Xiaoming Wang and Zhiheng Xu for discussion,Ruxiao Xing,Xudong Liu and Jinquan Gao for technical assistance,Yafeng Luo Guangzhou Yuanxi Biotech Co.,Ltd for animal resource and care,and Samuel Hulbert for critical reading of the manuscript.The project was supported by the2014CB942803 and 2016YFA0501000;the Strategic Priority Research Program of the Chinese Academy of SciencesXDB02020400;the National Natural Science Foundation of China31110103907,91332206 and 31490592

在线出版日期：2017-11-30（万方平台首次上网日期，不代表论文的发表时间）

页数：共5页

页码：1293-1297