Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding

摘要：

Dear Editor,Cell replacement therapy holds great therapeutic promise towards restoring tissue homeostasis.However,aging-associated functional decay and neoplastic transformation following transplantation must be overcome before cell therapies can be effectively and safely implemented in the clinical settings ”1-4”.This goal can theoretically be achieved by developing enhancement strategies towards endowing stem cells with more robust regenerative capacities and concomitantly,a reduced risk for tumorigenesis ”5,6”.Here,we provide an experimental and conceptual strategy on how to genetically engineer superior and safer stem cells.

机标关键词：neoplastic transformation、stem cells、replacement therapy

所属期刊栏目：27

分类号：R31;R3

资助基金：the National Key R&D Program of China2015CB964800,2017YFA0103300,2017YFA0102700,2014CB910503,2014CB964600;the National High Technology Research and Development Program of China2015AA020307;CASXDA01020312,KJZDEW-TZ-L05,and CXJJ-16M271;the National Natural Science Foundation of China81625009,81330008,31222039,81371342,81300261,81271266,81471414,81422017,81401159,31671429,81601233,81671377,31601109,31601158,81561138005,31625018 and 81521002;Beijing Natural Science Foundation7141005 and 5142016;Program of Beijing Municipal Science and Technology CommissionZ151100003915072;the Thousand Young Talents Program of China,and the State Key Laboratory of Stem Cell and Reproductive Biology 2016SRLab- KF13. WZ was supported by NIH grants CA158055,CA200673,and CA203834,the V Scholar award,American Cancer Society seed grant,Breast Cancer Research Award and Oberley Award Natio2012-PG-MED002;the Moxie Foundation

在线出版日期：2017-10-16（万方平台首次上网日期，不代表论文的发表时间）

页数：共4页

页码：1178-1181