SMAD5 signaling: more than meets the nuclei

摘要：

SMADs are essential transcriptional effectors of transforming growth factor-β (TGFβ)/TGFβ-related signaling that underlies embryonic development and adult homeostasis.A recent study by Fang et al.in Cell Research adds to this biological complexity by demonstrating an atypical cytoplasmic role for SMAD5 in modulating the bioenergetic homeostasis (i.e.,glycolysis and mitochondrial respiration) of cells in response to fluctuations in intracellular pH that is independent of receptor signaling.

机标关键词：embryonic development、biological complexity、intracellular pH

所属期刊栏目：27

分类号：S8 ;R99

在线出版日期：2017-10-16（万方平台首次上网日期，不代表论文的发表时间）

页数：共2页

页码：1075-1076