Clonal analysis reveals remarkable functional heterogeneity during hematopoietic stem cell emergence

摘要：

Dear Editor,In conventional opinion,hematopoietic stem cells (HSCs) are alike,possessing robust self-renewal and multilineage differentiation capacity.However,growing evidence has revealed striking functional heterogeneity among individual HSCs,particularly in the aspect of lymphomyeloid output ”1-3”.Four subtypes of HSCs with distinct differentiation patterns have been identified and designated as α-,β-,γ-,and δ-HSCs ”4”.Only lymphoid-deficient (α) and lymphomyeloid-balanced (β) HSCs bear durable engraftment potential and extensive self-renewal activity ”5”.Although differentiation program of individual HSCs can be stably self-propagated,occasional occurrence of inter-conversions among programs has also been observed ”5”.HSC heterogeneity exhibits developmental stage-related fluctuation,especially regarding the prevalence of α-HSCs,being minor in fetal liver but high in aging bone marrow (BM) ”5”.The arising concept of HSC heterogeneity leads to a series of key questions,as to its embryonic origin,regulatory mechanisms,and relationship with leukemogenesis and therapeutics.

机标关键词：fetal liver、bone marrow、stem cells

所属期刊栏目：27

分类号：R31;R78

资助基金：the National Key Research and Development Program of China,Stem Cell and Translational Research2016YFA0100601;the Chinese National Key Program on Basic Research2011CB964800;the National Natural Science Foundation of China31425012,31371185,81400076,31322037,81561138005,81421002,81561138003,81370596,and 91439128;the State Key Laboratory of ProteomicsK201502

在线出版日期：2017-09-15（万方平台首次上网日期，不代表论文的发表时间）

页数：共4页

页码：1065-1068