Repolarizing macrophages improves breast cancer therapy
Tumor-associated macrophages (TAMs) contribute to breast cancer progression and dissemination;TAM-targeting strategies aimed at their reprogramming show promising preclinical results.In a new report Guerriero and colleagues demonstrate that a novel HDAC Class Ⅱa inhibitor,TMP195,can reprogram monocytes and macrophages in the tumor into cells able to sustain a robust CD8 T cell-mediated anti-tumoral immune response.
immune response、breast cancer
27
TP3;R81
2017-09-15(万方平台首次上网日期,不代表论文的发表时间)
共2页
963-964