Optogenetic activation of dorsal raphe neurons rescues the autistic-like social deficits in Shank3 knockout mice

摘要：

Dear Editor,Impaired social interaction is one of the core symptoms of the autism spectrum disorder (ASD) ”1”.However,the etiology and neural circuit mechanisms underlying these behavioral impairments are not well understood ”2”.Currently,behavioral therapies are the most effective interventions for ASD,although the benefits from such treatments are minimal ”3,4”.Here,we demonstrate that the autistic-like social deficits of Shank3 knockout mice ”5” can be durably rescued by social training coupled with optogenetic activation of neurons in the midbrain dorsal raphe nucleus (DRN) — a region encoding reward through 5-HT and glutamate ”6”.A single training session resulted in a significant rescue effect on social preference,and such rescue effect was retained for several days with increased neuronal activation in the DRN when facing social stimuli.Multiple training sessions resulted in much longer-lasting rescue effects.

机标关键词：dorsal raphe nucleus

所属期刊栏目：27

分类号：R3

资助基金：ML is supported by Ministry of Science and Technology of China2012YQ03026005,2013zx0950910,2015BAI08B02;National Natural Science Foundation of China91432114,91632302;the Beijing Municipal Government

在线出版日期：2017-08-24（万方平台首次上网日期，不代表论文的发表时间）

页数：共4页

页码：950-953