Global profiling of crotonylation on non-histone proteins

摘要：

Dear Editor,Lysine crotonylation is a posttranslational modification (PTM) of histone proteins originally identified by Tan et al.”1”.This novel evolutionarily conserved histone modification was identified on 28 lysine sites on various histones ”1”.Lysine crotonylation occurs primarily on the ε-amino group of lysine,but its planar orientation and four-carbon length distinguish it from lysine acetylation.Histone crotonylation specifically labels the enhancers and transcription starting sites of active genes in both the human somatic cell genome and the murine male germ cell genome.Histone crotonylation,like acetylation,affects chromatin structure and facilitates histone replacement in elongating spermatids ”1”.Recently YEATS domain-containing protein YEATS2 was found to be a selective histone crotonylation reader ”2”.

机标关键词：germ cell

所属期刊栏目：27

分类号：R31

资助基金：This study was supported by the Ministry of Science and Technology of China2016YFC1302103,2015CB553906,and 2013CB910501;the National Natural Science Foundation of China81230051,81472734,31170711,81321003,81301802 and 30830048;the Beijing Natural Science Foundation7171005;the 111 Project of the Ministry of Education,Peking UniversityBMU20120314 and BMU20130364;a Leading Academic Discipline Project of Beijing Education Bureau to HZ

在线出版日期：2017-08-24（万方平台首次上网日期，不代表论文的发表时间）

页数：共4页

页码：946-949