Beyond growth signaling: Paneth cells metabolically support ISCs
Single Lgr5+ intestinal stem cells (ISCs) can be expanded in vitro into epithelial organoids or ”mini-guts”,self-organizing cellular structures that recreate the intestinal differentiation program;Paneth cells,which constitute the intestinal stem cell niche,secrete stem cell growth signals,and are thus essential for this process.In a recent paper published in Nature,Rodríguez-Colman et al.describe how Paneth cells may be supporting the metabolic state of ISCs.
cellular structures、stem cells、cell growth、in vitro
27
=化;R93
2017-08-24(万方平台首次上网日期,不代表论文的发表时间)
共2页
851-852