Reversible transition between hepatocytes and liver progenitors for in vitro hepatocyte expansion

摘要：

Dear Editor,Liver exhibits robust regeneration following mechanical damage due to immediate proliferation of hepatocytes.It has been recently reported that hepatocyte replenishment following liver damage could also occur via a reversible transition between hepatocytes and duct-like progenitor cells ”1”.Hepatocyte-derived duct-like progenitor cells were observed to expand extensively in the presence of toxic insults and re-differentiate into functional hepatocytes upon cessation of injury ”1”.This process was identified as ductal metaplasia of adult hepatocytes in vivo and described as an alternative mechanism for hepatocytes to escape from various chronic injuries ”1,2”.Given the highly proliferative potential of the in vivo hepatocyte-derived progenitor cells,we sought to determine whether an optimal culture condition mimicking the in vivo milieu could be developed to extensively expand functional hepatocytes through reversible transition in vitro.

机标关键词：progenitor cells、mechanical damage、liver damage、in vitro

所属期刊栏目：27

分类号：R3 ;S71

资助基金：the National Key R&D Program2016YFC1101402;the National Natural Science Foundation of China31371440,31571477 and 81471948;Program of Shanghai Academic/Technology Research Leader16XD1403300

在线出版日期：2017-06-08（万方平台首次上网日期，不代表论文的发表时间）

页数：共4页

页码：709-712