Cell fate conversion: a chromatin remodeling checkpoint revealed
In a new paper in CeflResearch,Ji et aL find that transcription factor-in-stigated opening of chromatin,during cell reprogramming,can be sensed by the Baf60b-containing chromatin remodeling complex,which then activates the ATM-p53 pathway,leading to cell death.These findings from reprogramming studies unveil what I term a ”chromatin remodeling checkpoint” whereby extensive,inappropriate chromatin opening events lead to cell elimination,thus preventing cell fate conversion that might occur upon tissue damage;if unchecked,such conversion could lead to metaplasia and cancer.
cell death、paper in
27
R97;R73
2017-06-08(万方平台首次上网日期,不代表论文的发表时间)
共2页
598-599