Single-cell exome sequencing identifies mutations in KCP, LOC440040, and LOC440563 as drivers in renal cell carcinoma stem cells

摘要：

Dear Editor,Renal cell carcinoma (RCC) accounts for ～3％ of adult malignancies and 90％-95％ of kidney neoplasms ”1”.Metastatic disease is usually resistant to radiation and chemotherapy.Immunotherapy shows limited response rates of 15％ to 20％ ”2”.Cancer stem-like cells (CSCs)are key players in RCC initiation,development and resistance to therapy ”3”.Previous studies have shown that RCC is a genetically distinct adult carcinoma with a relatively low mutation rate ”4”.Sequencing analyses have revealed that some common somatic mutations are shared among RCC patients ”5”.Recently,single-cell exome sequencing has been used to evaluate somatic mutations in many tumor types ”6”.However,a systematic effort applying this new technique to identify key driver genes in the CSCs of RCC has not been made.

机标关键词：stem cells、kidney neoplasms、new technique、mutation rate

所属期刊栏目：27

分类号：R73;O1

资助基金：the National Natural Science Foundation of China81472413 and 81472679;863 ProgramSS2014AA020607 and 2015AA020405;tbe National Key Research and Development Program2016YFC0902603

在线出版日期：2017-05-23（万方平台首次上网日期，不代表论文的发表时间）

页数：共4页

页码：590-593