Hypoxia potentially promotes Tibetan longevity
Dear Editor,The lifespans of model animals,such as Caenorhabditis elegans,have been demonstrated to be extended when they are subjected to hypoxic conditions in the laboratory ”1,2”.In addition,wild mammals with hypoxic habitats,such as the naked mole rat that lives in burrow,and whales that must hold their breath as they dive,seem to live longer ”3-5”.In stark contrast with observations in the laboratory,humans living under natural hypoxic environment of the Tibetan Plateau have generally been thought to have much shorter lifespans compared with people living at lower altitudes.No scientific ascertainment exists for this paradox,neither has the underlying genetic basis been resolved.
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DDW was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences XDB13020600.YL was supported by the National Natural Science Foundation of China 31401083.DDW,WW,PS and YPZ were supported by the National Natural Science Foundation of China 31321002.
2017-03-23(万方平台首次上网日期,不代表论文的发表时间)
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