Autophagic membrane delivery through ATG9

摘要：

One of the key questions regarding macroautophagy/autophagy is the mechanism through which the transmembrane protein ATG9 functions in delivering membrane to the expanding phagophore,the sequestering compartment that matures into an autophagosome.In a recent study,Zhou et al.identified a novel mechanism that regulates ATG9 trafficking from the plasma membrane and trans-Golgi network,which involves two conserved sorting signals required for ATG9 interaction with the AP1/2 adaptor complex and phosphorylation of ATG9 at Tyr8 by SRC kinase and at Ser14 by ULK1 for proper function during basal and starvation-induced autophagy.

所属期刊栏目：27

在线出版日期：2017-03-23（万方平台首次上网日期，不代表论文的发表时间）

页码：161-162