Mechanisms of activation and inhibition of Zika virus NS2B-NS3 protease
Dear Editor,Since ZIKV outbreak was first reported in South and Central America and the Caribbean,it has spread to both North America and Asia ”1”.Preliminary reports have now estimated as many as 1.3 million cases of infection in this widespread epidemic ”2”.Initially it was thought that the ZIKV only causes mild symptoms such as fever,myalgia,and rash;recent studies have revealed that ZIKV can also cause severe neurological pathologies such as neonatal microcephaly and Guillain-Barre syndrome ”3”.
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This work was supported by National Key Basic Research Program of China 973 program 2015CB859800,National Key Research Program of China 2016YFD0500300,and National Natural Science Foundation of China 31528006 and 31470730.
2016-12-24(万方平台首次上网日期,不代表论文的发表时间)
1260-1263