The genome-wide mutational landscape of pituitary adenomas
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Dear Editor,Pituitary adenomas (PAs) are one of the most common intracranial tumors,which can result in significant morbidity and can cause mortality either by exerting central pressure effects from the pituitary mass or by secreting excessive pituitary hormones ”1”.Depending on their capability to produce hormones,PAs are classified as clinically functioning and nonfunctioning (NF).Functioning PAs include 6 subtypes,characterized by hypersecretion of prolactin (PRL),growth hormone (GH),adrenocorticotropin (ACTH),gonadotropins including follicle stimulating hormone and luteinizing hormone (GT),thyrotropin (TSH) or multiple hormones (plurihormonal),respectively.We and other group recently reported the recurrent genetic mutations in ACTH-PAs ”2,3”.Previous studies also identified genetic alterations in GH-PAs by wholegenome and-exome sequencing ”4,5” and in 7 NF-PAs by exome analysis ”6”.Due to challenges in collection and preparation of PA samples,exome-wide sequencing of other subtypes,including the PRL-,GT-,TSH-,and plurihormonal PA subtypes,has not been reported yet.
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This work was supported by China Pituitary Adenoma Specialist Council CPASC,and the National High Technology Research and Development Program of China 2014AA020611,the National Program for Support of Top-Notch Young Professionals,the National Natural Science Foundation of China 81172391,the Shanghai Rising-Star Tracking Program 12QH1400400 to Yao Zhao;the Natural Natural Science Foundation of China 31325014,81272302,the National Program for Support of Top-Notch Young Professionals,Shanghai Key Laboratory of Psychotic Disorders 13dz2260500 to Yongyong Shi.