A CRISPR evolutionary arms race: structural insights into viral anti-CRISPR/Cas responses
Dear Editor,CRISPR/Cas systems are widespread RNA-mediated prokaryotic adaptive immune systems providing protection against invading nucleic acids ”1”.However,throughout evolution,this host defense system has not resulted in the eradication of phages,suggesting that phages have evolved counter strategies to thrive within bacteria despite these mechanisms ”2”.Thus,both bacterial CRISPR system and phage anti-CRISPR system are part of a continuing evolutionary battle between bacterial host and their bacteriophage invaders.
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This work was supported by grants from the National Natural Science Foundation of China 91440201,31571335,31400640 and 31570874,the Chinese Ministry of Science and Technology 2014CB910102and the Strategic Priority Research program of the Chinese Academy of Sciences XDB08010203.
2016-11-23(万方平台首次上网日期,不代表论文的发表时间)
1165-1168