Structural basis of prokaryotic NAD-RNA decapping by NudC

摘要：

Dear Editor,In eukaryotes,the 5”,5”-triphosphate-linked 7-methylguanosine (m7G) cap is essential for modulation of mRNA metabolism and protects the mRNA from degradation ”1”.Removal of the cap from the 5”-terminus of the RNA is mainly carried out by decapping protein 2 (Dcp2) ”2,3” and scavenger decapping enzyme (DcpS) ”4”.A distinctive feature of prokaryotic mRNA is the absence of a 5”-capped structure.Recently,nicotinamide adenine dinucleotide (NAD) or a triphosphate group has been shown to be covalently linked to the 5”-end of certain types of prokaryotic RNAs ”5,6” as a cap that improves stability,and NADH pyrophosphatase (NudC) ”6” and RNA pyrophosphohydrolase (RppH) ”7” are responsible for the 5” hydrolysis of NAD or the triphosphate group,respectively,from the RNA.

所属期刊栏目：26

资助基金：This work was supported by funds from the Ministry of Science and Technology grant number 2015CB910900,Fok Ying-Tong Education Foundation grant 151021,the Fundamental Research Funds for the Central Universities Program No.2014PY026,No.2015PY219,and No.2014JQ001,and Huazhong Agricultural University Scientific & Technological Self-innovation Foundation Program No.2013RC013.

在线出版日期：2016-10-28（万方平台首次上网日期，不代表论文的发表时间）

页码：1062-1066