Mitochondrial fusion fuels T cell memory
Differences in mitochondrial structures determine the metabolic landscape of effector and memory T cell populations in vivo.Proliferating lymphocytes and cancer cells use the ‘Warburg effect’ in which cells switch from more energy-efficient oxidative phosphorylation (i.e.,the mitochondrial break-up of nutrients) to aerobic glycolysis (i.e.,the cytoplasmic oxidation of glucose into pyruvate) to generate building blocks for growth.
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2016-10-28(万方平台首次上网日期,不代表论文的发表时间)
969-970