Electrophysiologist shows a cation channel function of MLKL
Whether mixed lineage kinase domain-like (MLKL) mediates necroptosis by forming ion channel,noneselective pore,or simply by disrupting plasma membrane is unclear.In a paper published in recent issue of Cell Research,Yia et al.showed that MLKL functions as a novel class of cation channel.Necroptosis is a type of programmed cell death with necrotic morphology.In recent years,scientists have provided us with many details in molecular mechanism of necroptosis and uncovered its function in many physiological and pathological processes.
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2016-07-14(万方平台首次上网日期,不代表论文的发表时间)
643-644