MYC——a thorn in the side of cancer immunity
For decades,MYC has been known for its role in regulating cancer cell proliferation and survival.In a recent paper published in Science,Casey et al.have uncovered a new function for MYC in promoting immune evasion by directly regulating expression of programmed death-ligand 1 (PD-L1)and CD47 on cancer cells.The MYC transcription factor regulates many genes involved in cell proliferation and survival,and is commonly overexpressed in human cancer ”1”.
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2016-07-14(万方平台首次上网日期,不代表论文的发表时间)
639-640