Recent progress in ubiquitin and ubiquitin-like protein (Ubl) signaling

摘要：

Ubiquitin (Ub),a 76-residue polypeptide that is present in all eukaryotes,can be covalently conjugated to other proteins or other Ub molecules.Such ubiquitination (or ubiquitylation) reactions involve a cascade of reactions catalyzed by E1 (ubiquitin-activating enzyme),E2 (ubiquitin-conjugating enzyme) and E3 (ubiquitin ligase)proteins.The human Ub system encompasses ～40 E2s and ～700 E3s that specifically recognize and conjugate Ub to their substrates,including other Ub molecules.Protein ubiquitination is reversed by deubiquitinating enzymes (DUBs),which number close to 100in humans.

所属期刊栏目：26

在线出版日期：2016-05-09（万方平台首次上网日期，不代表论文的发表时间）

页码：389-390