Pathway mining-based integration of critical enzyme parts for de novo biosynthesis of steviolglycosides sweetener in Escherichia coil

摘要：

Dear Editor,The development of microbial synthetic biology has been revolutionizing the industrial production of important plant terpenoids since the dawn of the century ”1,2”.By reconstructing the downstream biosynthetic pathways and systematically engineering the supply of common terpenoid precursors,the engineered microorganism chassis (e.g.,Escherichia coli and Saccharomyces cerevisiae) can produce desired terpenoids in a more controllable manner.This strategy is also adapted to enrich the knowledge of cell metabolism via either discovery of novel or proof of postulated pathways ”3”.

所属期刊栏目：26

资助基金：This work was supported by the National Basic Research Program of China ”973” Program,2012CB721104,the National High Technology Research and Development Program ”863” Program,2012AA02A701,and the Key Projects of Shanghai Committee of Science and Technology 14JC1406900.

在线出版日期：2016-04-21（万方平台首次上网日期，不代表论文的发表时间）

页码：258-261