CRISPR/Cas9-mediated genome engineering of the ferret

摘要：

Dear Editor,Ferrets (Mustela putorius furo) have served as one of the most valuable animal models for recapitulating human disease since 1933 ”1”.This is because they show many similarities to humans in terms of physiological features of brain function and reproductive biology as well as pathological characteristics of various diseases such as cancer, influenza infection and cystic fibrosis ”2-4”.Despite these advantages, the current use of ferrets in research is significantly limited due to the lack of a method enabling precise genetic modification.

所属期刊栏目：25

资助基金：This work was supported by grants from the National Basic Research Program of China 2014CB964600, 2012CBA01300 and 2012CB966800, the Strategic Priority Research Program of the Chinese Academy of Sciences XDA01020309, the National Natural Science Foundation of China NSFC;31371100, 91332105, 31400937, 31400938 and 31400939, and the Thousand Young Talents Program of China.

在线出版日期：2016-01-21（万方平台首次上网日期，不代表论文的发表时间）

页码：1372-1375