Loss of the sulfate transporter Slc13a4 in placenta causes severe fetal abnormalities and death in mice
Dear Editor,Sulfate is an obligate nutrient for numerous cellularand metabolic processes important for fetal development”1”.Fetal tissues express sulfotransferases which conjugate sulfate (sulfonate) to molecules such as steroids and hormones, leading to their inactivation ”2”.In addition, sulfonation of glycosaminoglycans is important for development of some tissues, as several growth factor gradients and ligand-receptor interactions are dependent on these sulfonated extracellular constituents ”3”.Not surprisingly therefore, reduced sulfonation capacity has been linked to disorders of skeletal, eye, vascular and craniofacial development, demonstrating a critical requirement for sulfate in these tissues ”4”.
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This work was supported in part by NHMRC grant 569568 to D.G.Simmons and by generous support from the School of Biomedical Sciences and the Mater Research Institute, University of Queensland.
2015-12-10(万方平台首次上网日期,不代表论文的发表时间)
1273-1276