Direct conversion of astrocytes into neuronal cells by drug cocktail

摘要：

Dear Editor,Neurological disorder is one of the greatest threats to public health according to the World Health Organization.Because neurons have little or no regenerative capacity, conventional therapies for neurological disorders yielded poor outcomes.While the introduction of exogenous neural stem cells or neurons holds promise, many challenges still need to be tackled, including cell resource, delivery strategy, cell integration and cell maturation.Reprogramming of fibroblasts into induced pluripotent stem cells or directly into desirable neuronal cells by transcription factors (TFs) or small molecules can solve some problems, but other issues remain to be addressed, including safety, conversion efficiency and epigenetic memory ”1, 2”.

所属期刊栏目：25

资助基金：We thank all members of the lab for sharing reagents and advice.This work was supported by the Chinese Academy of Sciences XDA01010302, the Ministry of Science and Technology 2015CB964502, 2013CB966801 and 2011CB946102, the Ministry of Health 2012BAI10B03, the National Natural Science Foundation of China 31301129, the Shanghai Municipal Commission for Science and Technology 12ZR1452300, and the Samuel Waxman Cancer Research Foundation Co-PI Program.

在线出版日期：2015-12-10（万方平台首次上网日期，不代表论文的发表时间）

页码：1269-1272