aBETting therapeutic resistance by Wnt signaling
BET inhibition has emerged as a promising epigenetic therapy for malignancies in the last five years,but little consensus has developed regarding what may mediate the axis between sensitivity and resistance.Two recent papers published in Nature attempt to address this question in acute myeloid leukemia (AML) and independently identify the Wnt signaling pathway as a driver and biomarker of therapeutic resistance.
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2015-12-10(万方平台首次上网日期,不代表论文的发表时间)
1187-1188