Bromodeoxyuridine promotes full-chemical induction of mouse pluripotent stem cells
Dear Editor,Direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) with transcription factors (e.g.,Oct4 (O),Sox2 (S),Klf4 (K),and c-Myc (M)) greatly expands our understanding of cell fate control.iPSCs resemble embryonic stem cells (ESCs) but without immune rejection and ethic issues,and are therefore considered as a promising source for cell replacement therapy.
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This work was supported by the Chinese Academy of Sciences XDA01040301,the Ministry of Science and Technology of China 2015CB964503,and the National Natural Science Foundation of China 81425024 and 31371511.
2015-11-25(万方平台首次上网日期,不代表论文的发表时间)
1171-1174