How phosphoubiquitin activates Parkin
A recent report,solving the structure of a Parkin-phosphoubiquitin complex,greatly advances the understanding of the Parkin activation mechanism.Pinkl,a mitochondrial protein kinase,and Parkin,a cytosolic E3 ubiquitin ligase,mutated in hereditary forms of early onset Parkinson”s disease (PD),function together in mitochondrial maintenance.Pinkl is imported into healthy mitochondria with normal membrane potential,and then cleaved by the PARL protease and eventually degraded in the proteasome.
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2015-11-25(万方平台首次上网日期,不代表论文的发表时间)
1087-1088