Structural basis of the Norrin-Frizzled 4 interaction

摘要：

Dear Editor,Norrin,also known as the Norrie disease protein or X-linked exudative vitreoretinopathy 2 protein,is a secreted retinal growth factor with angiogenic and neuroprotective properties.Mutations in the NPD gene,which encodes the Norrin protein,are associated with Norrie disease,familial exudative vitreoretinopathy (FEVR),retinopathy of prematurity (ROP),and other retinal hypovascularization diseases ”1,2”.

所属期刊栏目：25

资助基金：We thank staff members of the Life Science Collaborative Access Team ID-21 of the Advanced Photon Source APS for assistance in data collection at the beam lines of sector 21,which is in part funded by the Michigan Economic Development Corporation and the Michigan Technology Tri-Corridor Grant 085P1000817.Use of APS was supported by the Office of Science of the US Department of Energy,under Contract No DE-AC02-06CH11357.We also thank staff members of the Berkeley Center for Structural Biology of the Advanced Light Source ALS.Use of ALS was supported by the Director,Office of Science,Office of Basic Energy Sciences,of the US Department of Energy under Contract No DE-AC02-05CH11231.This work was supported by National Institute of Health EY026044 to WX,DK071662 to HEX,and GM102545 and GM104212 to KM and by the Van Andel Research Institute HEX and KM.

在线出版日期：2015-10-23（万方平台首次上网日期，不代表论文的发表时间）

页码：1078-1081