DNA damage and gene transcription: accident or necessity?
The extent to which DNA repair machinery facilitates gene activation remains poorly appreciated.A new study published in Cell Research reports a novel function of H2AX,a substrate of ATM and known DNA damage marker,in transcriptional initiation.In eukaryotic cells,genomic DNA is organized in chromatin.The repeating unit of chromatin is the nucleosome core particle containing histones with bound DNA.
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2016-05-12(万方平台首次上网日期,不代表论文的发表时间)
769-770