Targeted genome editing in primate embryos
Mosaic mutations and off-target effects caused by CRISPR/Cas9 have led to concerns about the efficiency and specificity of this new technique in non-human primates and other large animals.Here we discuss recent findings from primate embryos,with a focus on the technical issues CRISPR/Cas9 faces before producing non-human primate models of human diseases.
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2016-05-12(万方平台首次上网日期,不代表论文的发表时间)
767-768