A price to pay for tumor regression
Killing cancer cells can have undesired side effects.Upon drug treatment,drug-sensitive cancer cells secrete an array of growth factors that stimulate the proliferation and dissemination of drug-resistant cells in the population.Acquired resistance to therapy represents a formidable hurdle to the successful treatment of cancer.This is true both for conventional chemotherapeutic regimen and the more recent ”targeted” cancer drugs that act selectively on the pathways that are deregulated in cancer.
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2016-05-12(万方平台首次上网日期,不代表论文的发表时间)
763-764